期刊
FASEB JOURNAL
卷 34, 期 8, 页码 11143-11167出版社
WILEY
DOI: 10.1096/fj.201903005RR
关键词
brown adipose; mitochondria; muscle; PEMF; white adipose
资金
- Lee Foundation, Singapore [N-176-000-045-001]
- Institute for Health Innovation & Technology, iHealthtech (Microbiome in Health, Disease and Ageing), at the National University of Singapore [R-176-000-243-731]
- Ministry of Education Academic Research Fund [R-722-000-018-112, MOE2018-T2-2-158]
- European Space Agency Grant ESA-CORAGBF [4000113883]
- Fondation Suisse de Recherche sur les Maladies Musculaires
Exercise modulates metabolism and the gut microbiome. Brief exposure to low mT-range pulsing electromagnetic fields (PEMFs) was previously shown to accentuate in vitro myogenesis and mitochondriogenesis by activating a calcium-mitochondrial axis upstream of PGC-1 alpha transcriptional upregulation, recapitulating a genetic response implicated in exercise-induced metabolic adaptations. We compared the effects of analogous PEMF exposure (1.5 mT, 10 min/week), with and without exercise, on systemic metabolism and gut microbiome in four groups of mice: (a) no intervention; (b) PEMF treatment; (c) exercise; (d) exercise and PEMF treatment. The combination of PEMFs and exercise for 6 weeks enhanced running performance and upregulated muscular and adiposePgc-1 alpha transcript levels, whereas exercise alone was incapable of elevatingPgc-1 alpha levels. The gut microbiomeFirmicutes/Bacteroidetesratio decreased with exercise and PEMF exposure, alone or in combination, which has been associated in published studies with an increase in lean body mass. After 2 months, brief PEMF treatment alone increasedPgc-1 alpha and mitohormetic gene expression and after >4 months PEMF treatment alone enhanced oxidative muscle expression, fatty acid oxidation, and reduced insulin levels. Hence, short-term PEMF treatment was sufficient to instigate PGC-1 alpha-associated transcriptional cascades governing systemic mitohormetic adaptations, whereas longer-term PEMF treatment was capable of inducing related metabolic adaptations independently of exercise.
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