期刊
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS
卷 20, 期 9, 页码 905-911出版社
TAYLOR & FRANCIS AS
DOI: 10.1080/14737159.2020.1792781
关键词
Alpha-gal; antibody; allergy; interleukin; tick; mammalian meat
类别
资金
- Consejeria de Educacion, Cultura y Deportes, JCCM, Spain [CCM17-PIC-036, SBPLY/17/180501/000185]
Introduction The alpha-Gal syndrome (AGS) is a type of allergy characterized by an IgE antibody response against the carbohydrate Gal alpha 1-3Gal beta 1-4GlcNAc-R (alpha-Gal). Tick bites are recognized as the most important cause of anti-alpha-Gal IgE antibody increase in humans. Several risk factors have been associated with the development of AGS, but their integration into a standardized disease diagnosis has proven challenging. Areas covered Herein we discuss the current AGS diagnosis based on anti-alpha-Gal IgE titers and propose an algorithm that considers all co-factors in the clinical history of alpha-Gal-sensitized patients to be incorporated into the AGS diagnosis. The need for identification of host-derived gene markers and tick-derived proteins for the diagnosis of the AGS is also discussed. Expert opinion The current AGS diagnosis based on anti-alpha-Gal IgE titers has limitations because not all patients sensitized to alpha-Gal and with anti-alpha-Gal IgE antibodies higher than the cutoff (0.35 IU/ml) develop anaphylaxis to mammalian meat and AGS. The basophil activation test proposed to differentiate between patients with AGS and asymptomatic alpha-Gal sensitization cannot be easily implemented as a generalized clinical test. In coming years, the algorithm proposed here could be used in a mobile application for easier AGS diagnosis in the clinical practice.
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