期刊
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY
卷 19, 期 1, 页码 35-44出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14787210.2020.1810569
关键词
Bacterial infections; antibiotic resistance; graphene oxide quantum dot; graphene quantum dots; carbon quantum dot; carbon nanotube; photodynamic therapy
The emergence of antibiotic resistance in bacteria, especially in treating infectious immunodeficiency related diseases, is a complex issue. Nanomaterials (NMs) have played a novel role in treating bacterial infections compared to bulk materials. Carbon-containing quantum dots (QDs) like graphene oxide QD (GOQD), graphene QD (GQD), and carbon QD (CQD) have shown bacteriostatic and bactericidal activities against antibiotic-resistant bacteria. The stability and biocompatibility of QDs at higher doses in physiological conditions are major concerns, which can be addressed through functionalization. Additionally, the aspect ratio (AR) of carbon nanotubes (CNTs) like single-wall carbon nanotubes (SWCNTs) and multiwall carbon nanotubes (MWCNTs) is a determining factor for antibacterial value, with SWCNTs showing higher antibacterial ability than MWCNTs.
Introduction Emergence of antibiotic resistance in bacteria is a complicated issue, especially when treating infectious immunodeficiency related diseases. In recent years, when compared to bulk materials, nanomaterials (NMs) with specific antibacterial activities have played a novel role in treating bacterial infections. Among NMs, quantum dots (QDs), specifically carbon containing QDs including graphene oxide QD (GOQD), graphene QD (GQD), and carbon QD (CQD), have demonstrated bacteriostatic and bactericidal activities via photodynamic (PD) effects against antibiotic resistant bacteria under a certain wavelength of light. Area covered In this mini-review, recent advances and challenges related to antibacterial and biocompatibility activities of modified GQD, GOQD, CQD, and carbon nanotubes (CNTs) are discussed. Expert opinion Lower stability and biocompatibility of QDs at higher doses in physiological conditions are major disadvantages. In this regard, functionalization of these QDs can result in appropriate bactericidal, biocompatibility, and biodegradability properties. In the case of CNTs including single-wall carbon nanotube (SWCNTs) and multiwall carbon nanotube (MWCNTs), aspect ratio (AR) is a determinant factor for the antibacterial value. Moreover, MWCNTs show a lower antibacterial ability compared to SWCNTs, which can be improved by modifying their surface.
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