Central and peripheral muscle fatigue following repeated-sprint running in moderate and severe hypoxia

We examined the effects of increasing hypoxia severity on repeated-sprint running performance and neuromuscular fatigue. Thirteen active males completed eight sprints of 5 s (recovery = 25 s) on a motorized sprint treadmill in normoxia (sea level, SL; F-I,F- O2 = 0.21), in moderate hypoxia (MH; F-I,F- O2 = 0.17) and in severe hypoxia (SH; F-I,F- O2 = 0.13). After 6 min of passive recovery, in all conditions a second set of four sprints of 5 s was conducted in normoxia. Neuromuscular function of the knee extensors was assessed at baseline (Pre-) and 1 min after set 1 (Post-set 1) and set 2 (Post-set 2). In set 1, the mean distance covered in SL (22.9 +/- 1.2 m) was not different to MH (22.7 +/- 1.3 m; P = 0.71) but was greater than in SH (22.3 +/- 1.3 m; P = 0.04). No significant differences between conditions for mean distance occurred in set 2. There was a decrease in maximal voluntary contraction torque (Delta = -31.4 +/- 18.0 N m, P < 0.001) and voluntary activation (%VA; Delta = -7.1 +/- 5.1%, P = 0.001) from Pre- to Post-set 1, but there was no effect of hypoxia. No further change from Post-set 1 to Post-set 2 occurred for either maximal voluntary contraction or %VA. The decrease in potentiated twitch torque in SL (Delta = -13.3 +/- 5.2 N m) was not different to MH (Delta = -13.3 +/- 6.3 N m) but was lower than in SH (Delta = -16.1 +/- 4 N m) from Pre- to Post-set 1 (interaction, P < 0.003). Increasing severity of normobaric hypoxia, up to an equivalent elevation of 3600 m, can increase indices of peripheral fatigue but does not impact central fatigue after 'all-out' repeated-sprint running.

Automated summary

Increasing severity of normobaric hypoxia, up to an equivalent elevation of 3600 m, can increase indices of peripheral fatigue but does not impact central fatigue after 'all-out' repeated-sprint running.