Diffusion tensor imaging with fiber tracking provides a valuable quantitative and clinical evaluation for compressed lumbosacral nerve roots: a systematic review and meta-analysis

Purpose This study aimed to investigate the diagnostic value of fractional anisotropy (FA) and apparent diffusion coefficient (ADC) of the diffusion tensor imaging (DTI) with fiber tracking in patients with compressed lumbosacral nerve roots. Methods A systematic literature search of databases (PubMed, Embase, Cochrane Library, and Web of Science) was carried out. FA values and ADC values were compared between compressed nerve roots and healthy controls. Pooled and subgroup analyses were performed using fixed or random-effect models based onI(2)heterogeneity. Results A total of 262 patients from ten studies with 285 compressed lumbosacral nerve roots and 285 contralateral normal nerve roots were included in the meta-analysis. It was showed in pooled results that FA value was significantly reduced (SMD - 3.03, 95% CI [ - 3.75 to - 2.31],P < 0.001) and ADC value was significantly increased (SMD 2.07, 95% CI [0.92 to 3.22],P < 0.001) in the compressed nerve roots, compared with contralateral normal nerve roots. Subgroup analysis comparing the FA values and ADC values in different nerve root ranges (L2-S1,L4-S1,L5-S1,L5,S1) revealed the different ranges of nerve roots were possible sources of heterogeneity. Conclusions This study showed that FA value reduction and ADC value increase were valuable indicators of compressed lumbosacral nerve roots. These changes may be related to the neurological symptoms of patients. DTI with fiber tracking can directly visualize and accurately locate the compression zone of nerve roots to help make surgical treatment plans, is more advanced than conventional MRI.

Automated summary

The study on compressed lumbosacral nerve roots using diffusion tensor imaging (DTI) showed that reduced FA values and increased ADC values are valuable indicators for diagnosis and treatment planning. DTI with fiber tracking is more advanced than conventional MRI in visualizing and locating compression zones of nerve roots for surgical plans.