期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2020, 期 41, 页码 6429-6432出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.202000970
关键词
Biomass; Carbohydrates; Dihydroquinazolinones; One-pot reactions; Reduction
资金
- CAPES-PRINT [88887.368237/2019-00]
- CNPq [140137/2018-1]
- FAPESP [2018/14150-8]
- Projekt DEAL
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [18/14150-8] Funding Source: FAPESP
Carbohydrates such as glucose are an abundant renewable resource that can be employed in synthetic processes as a source of carbon and/or hydrogen to yield products of high economical and biological impact. Herein, we report a versatile and environmentally friendly protocol for the one-pot synthesis of 2,3-dihydroquinazolin-4(1H)-ones, a privileged scaffold in medicinal chemistry, based on the use of glucose as an eco-friendly reductant in alkaline aqueous medium. This method can be viewed as a blueprint for the development of further one-pot sequences involving glucose as a reductant.
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