期刊
EUROPEAN JOURNAL OF NEUROSCIENCE
卷 53, 期 12, 页码 3811-3830出版社
WILEY
DOI: 10.1111/ejn.14887
关键词
cerebral small vessel disease; perineuronal extracellular matrix; perivascular extracellular matrix; stroke
资金
- Deutsche Forschungsgemeinschaft [RTG 2413]
- Federal state SaxonyAnhalt [ZS/2016/08/80645]
- European Structural and Investment Funds [ZS/2016/08/80645]
This article discusses the common complex mechanisms of various neurological and psychiatric diseases such as vascular damage, CNS injury, epilepsy, depression, multiple sclerosis, and cerebral small vessel disease. It also explores translational strategies to advance the development of new therapies for these conditions.
Vascular damage, central nervous system (CNS) injury, seizure or even psychological stress may trigger activation of microglia and infiltration of other immune cells, accompanied by high levels of expression and activity of extracellular proteases, such as matrix metalloproteinases (MMPs), and degradation/remodelling of the perivascular and perineuronal extracellular matrix (ECM). This acute response is followed by the recovery/chronic phase, during which the activation of astrocytes leads to the upregulated synthesis of ECM molecules, which, in combination with elevated expression of tissue inhibitor of metalloproteinases (TIMP) proteins, increases the aggregation of ECM molecules. This biphasic dysregulation of local balance between extracellular proteases and the ECM activates multiple temporally overlapping signalling cascades, involving receptor-type protein tyrosine phosphatases, integrins, Toll-like receptors, cell adhesion molecules, and ion channels, resulting in impaired synaptic plasticity and cognition. An additional level of complexity is related to the leakage of blood plasma proteins, such as fibrinogen, and the diffusion of perivascularly overproduced MMPs, TIMPs and ECM molecules into the CNS parenchyma, leading to diverse effects on neurons and incorporation of these molecules into the interstitial neural ECM. This review aims to outline these complex common mechanisms in stroke, CNS injury, depression, epilepsy, multiple sclerosis and cerebral small vessel disease and to discuss translational strategies to advance the development of new therapies for these neurological and psychiatric diseases.
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