期刊
EUROPEAN JOURNAL OF DERMATOLOGY
卷 30, 期 3, 页码 243-250出版社
JOHN LIBBEY EUROTEXT LTD
DOI: 10.1684/ejd.2020.3770
关键词
K17; paeoniflorin; proliferation; psoriasis
类别
资金
- National Natural Science Foundation of China [81673051]
- Shaanxi scientific research grant [2018SF-334, 2018JQ8059, 2016KTZDSF02-05]
Background Psoriasis is a common inflammatory skin disease characterized by hyperproliferation of epidermal keratinocytes, however, there is still no curative therapy for psoriasis. Paeoniflorin (PF), a Chinese herbal medicine, has shown anti-inflammatory effects. Objectives We aimed to illustrate the effect and associated mechanism of PF on keratinocyte proliferation using the IMQ-induced psoriasis mouse model. Materials and Methods The anti-psoriatic effect of PFin vivoandin vitrowas assessed by western blot, RT-PCR, immunofluorescence, cell counting kit-8 and haematoxylin/eosin staining. Results In vivo, epidermal thickness, dermal infiltrated lymphocytes and the level of several antimicrobial peptides, pro-inflammatory cytokines, and K17 were significantly reduced in mice with topical application of PF.In vitro, PF inhibited the proliferation of HaCaT cells in a dose-dependent manner, down-regulated K17 expression, and suppressed NF-kappaB activation. Conclusion Our findings indicate that PF may inhibit the proliferation of keratinocytes by targeting K17, suggesting that PF might be a potential target in the treatment of psoriasis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据