期刊
EUROPEAN JOURNAL OF CELL BIOLOGY
卷 99, 期 6, 页码 -出版社
ELSEVIER GMBH
DOI: 10.1016/j.ejcb.2020.151099
关键词
Splicing factors; SR proteins; SRSF; SRSF3; Cancer; Disease
类别
资金
- DBT [BT/PR10272/BRB/10/1266/2013, BT/PR8670/AGR/36/757/2013]
- DST-FIST [SR/FST/LS11-036/2014(C)]
- UGC-SAP [F.4.13/2018/DRSIII (SAP-II)]
- DBT-IISc Partnership Program Phase-II [BT/PR27952INF/22/212/2018]
The serine/arginine rich proteins (SR proteins) are members of a family of RNA binding proteins involved in regulating various features of RNA metabolism, including pre-mRNA constitutive and alternative splicing. In humans, a total of 12 SR splicing factors (SRSFs) namely SRSF1-SRSF12 have been reported. SRSF3, the smallest member of the SR family and the focus of this review, regulates critical steps in mRNA metabolism and has been shown to have mRNA-independent functions as well. Recent studies on SRSF3 have uncovered its role in a wide array of complex biological processes. We have also reviewed the involvement of SRSF3 in disease conditions like cancer, ageing, neurological and cardiac disorders. Finally, we have discussed in detail the autoregulation of SRSF3 and its implications in cancer and commented on the potential of SRSF3 as a therapeutic target, especially in the context of cancer.
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