期刊
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
卷 278, 期 1, 页码 109-115出版社
SPRINGER
DOI: 10.1007/s00405-020-06265-4
关键词
Dr. Theiss Rhino-Protect(R) PRS; Nose; Endoscopic sinus surgery; Postoperative care; Wound healing
资金
- Hanwha Pharma Co., Ltd. (Seoul, South Korea)
- Dr. Theiss Naturwaren GmbH (Homburg, Germany)
The application of Rhino-Protect after ESS significantly reduced pain, dryness, and crusting, leading to lower LK scores and improvements in edema and crust formation without any serious adverse events reported by patients.
Objective Blocking airflow into the sinonasal cavity after surgery may help to keep the cavity moist and thus decrease postoperative crusting. Here we investigated the efficacy of Rhino-Protect ointment following endoscopic sinus surgery (ESS). Subjects and methods A total of 93 patients with chronic rhinosinusitis who underwent identical ESS were enrolled. After surgery, all patients were instructed to perform nasal saline irrigation and deliver a nasal spray to each nostril, then to apply Rhino-Protect ointment to one nostril only; the other nostril served as a control. Subjective symptoms, postoperative Lund-Kennedy (LK) endoscopic scores, and adverse reactions 14 and 28 days after treatment were evaluated. Results The Rhino-Protect ointment significantly reduced pain (p = 0.015 at 28 days), dryness (p = 0.009 at 14 days andp = 0.045 at 28 days), and crusting (p = 0.047 at 14 days), and was associated with significantly lower LK scores 14 and 28 days after treatment (p = 0.037 andp = 0.007, respectively). Statistically significant differences were noted in the LK edema subscore at 14 days (p = 0.043) and in LK crusting subscores at 14 and 28 days (p = 0.005 andp = 0.006, respectively). No patient reported any serious adverse event associated with Rhino-Protect use. Conclusion Applying Rhino-Protect after ESS significantly reduced the formation of edema and crusts, leading to improving the patients' discomfort for pain, dryness, and crust.
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