期刊
EPIDEMIOLOGY AND INFECTION
卷 148, 期 -, 页码 -出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S095026882000179X
关键词
Coronavirus disease 2019; critically ill; meta-analysis; risk factors; severe disease
资金
- Emergency Science and Technology Brainstorm Project for the Prevention and Control of COVID-19, Guangxi Key Research and Development Plan [Guike AB20058002]
Our study aimed to systematically analyse the risk factors of coronavirus disease 2019 (COVID-19) patients with severe disease. An electronic search in eight databases to identify studies describing severe or critically ill COVID-19 patients from 1 January 2020 to 3 April 2020. In the end, we meta-analysed 40 studies involving 5872 COVID-19 patients. The average age was higher in severe COVID-19 patients (weighted mean difference; WMD = 10.69, 95%CI 7.83-13.54). Patients with severe disease showed significantly lower platelet count (WMD = -18.63, 95%CI -30.86 to -6.40) and lymphocyte count (WMD = -0.35, 95%CI -0.41 to -0.30) but higher C-reactive protein (CRP; WMD = 42.7, 95%CI 31.12-54.28), lactate dehydrogenase (LDH; WMD = 137.4, 95%CI 105.5-169.3), white blood cell count(WBC), procalcitonin(PCT?, D-dimer, alanine aminotransferase (ALT), aspartate aminotransferase (AST) and creatinine(Cr?. Similarly, patients who died showed significantly higher WBC, D-dimer, ALT, AST and Cr but similar platelet count and LDH as patients who survived. These results indicate that older age, low platelet count, lymphopenia, elevated levels of LDH, ALT, AST, PCT, Cr and D-dimer are associated with severity of COVID-19 and thus could be used as early identification or even prediction of disease progression.
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