期刊
ENVIRONMENTAL SCIENCE & TECHNOLOGY
卷 54, 期 18, 页码 11386-11395出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.est.0c01805
关键词
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资金
- Japan Society for the Promotion of Science (JSPS) [26220103, 16H02989, 19K22933]
- Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT), project on Joint Usage/Research Center-Leading Academia in Marine and Environment Pollution Research (LaMer), Ehime University
- Grants-in-Aid for Scientific Research [19K22933] Funding Source: KAKEN
Prenatal hydroxylated polychlorinated biphenyls (OH-PCBs) exposure may disrupt fetal brain development during the critical period of thyroid hormone (TH) action. However, there are limited studies on the OH-PCB transfer to the fetal brain, particularly in primates. In this study, we selected the Japanese macaque (Macaca fuscata) as a model animal for the fetal transfer of OH-PCBs in humans and revealed OH-PCB concentrations and their relationships in maternal and fetal blood, liver, and brain. L-thyroxine (T4)-like OH-PCBs including 4OH-CB187, a major congener in humans, were found in high proportions in the blood, liver, brain, and placenta of pregnant Japanese macaques. OH-PCBs were detected in the fetal brain and liver in the first trimester, indicating their transfer to the brain in the early pregnancy stage. 4OH-CB187 and 4OH-CB202 were the major congeners found in fetal brain, indicating that these T4-like OH-PCBs are transported from maternal blood to the fetal brain via the placenta. These results indicate that further studies are needed on the effects of OH-PCBs on the developing fetal brain.
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