期刊
ENVIRONMENTAL RESEARCH
卷 187, 期 -, 页码 -出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.envres.2020.109682
关键词
Bisphenol A; n-TiO2; Co-exposure; Bioaccumulation; Neurotoxicity; Zebrafish larvae
资金
- National Natural Science Foundation of China [21976207, 21806091]
- State Key Laboratory of Freshwater Ecology and Biotechnology [2019FBZ03]
The titanium dioxide nanoparticles (n-TiO2) could enhance the bioavailability and toxicity of the coexisted organic toxicants in aquatic phase. Parental co-exposure to n-TiO2 and bisphenol A (BPA) could generate developmental neurotoxicity in unexposed zebrafish offspring. However, it remains unexplored regarding the developmental neurotoxicity in larvae fish after co-exposure during the early developmental stage. In present study, fertilized zebrafish eggs were exposed to TiO2 nanoparticles (100 mu g/L), BPA (1, 4 and 20 mu g/L) or their binary mixtures until 6 days post fertilization (dpf). No significant change was observed in hatching, malformation, survival and weight of the larvae among all groups. However, n-TiO2 significantly increased the body burden of BPA in the 4 and 20 mu g/L co-exposure groups, depressed expression of neurodevelopment marker genes (al-tubulin, mbp and syn2a) as well as the locomotor behavior. The current results indicate that n-TiO2 could strengthen the developmental neurotoxicity and inactive locomotion in co-exposed zebrafish larvae by promoting the bioaccumulation and bioavailability of BPA, which highlighted the similar toxic risks of developmental neurotoxicity after co-exposure at early developmental stage to that of the parental co-exposure.
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