期刊
BMB REPORTS
卷 48, 期 11, 页码 618-623出版社
KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY
DOI: 10.5483/BMBRep.2015.48.11.041
关键词
Corneal alkali burn injury; Corneal inflammation; Corneal neovascularization; PEP-1-FK506BP; Protein therapy
资金
- Priority Research Centers Program grant [NRF-2009-0093812]
- Mid-Career Researcher Program grant through the National Research Foundation of Korea funded by the Ministry of Science, ICT & Future Planning [2012R1A2A2A06043084]
- Korean Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea [A120960]
- Hallym University [HRF-2015-01-014]
- National Research Foundation of Korea [2012R1A2A2A06043084] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
FK506 binding protein 12 (FK506BP) is a small peptide with a single FK506BP domain that is involved in suppression of immune response and reactive oxygen species. FK506BP has emerged as a potential drug target for several inflammatory diseases. Here, we examined the protective effects of directly applied cell permeable FK506BP (PEP-1-FK506BP) on corneal alkali burn injury (CAI). In the cornea, there was a significant decrease in the number of cells expressing pro-inflammation, apoptotic, and angiogenic factors such as TNF-alpha, COX-2, and VEGF. Both corneal opacity and corneal neovascularization (CNV) were significantly decreased in the PEP-1-FK506BP treated group. Our results showed that PEP-1-FK506BP can significantly inhibit alkali burn-induced corneal inflammation in rats, possibly by accelerating corneal wound healing and by reducing the production of angiogenic factors and inflammatory cytokines. These results suggest that PEP-1-FK506BP may be a potential therapeutic agent for CAI.
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