期刊
ENDOCRINE-RELATED CANCER
卷 27, 期 6, 页码 R163-R176出版社
BIOSCIENTIFICA LTD
DOI: 10.1530/ERC-19-0437
关键词
neuroendocrine tumors; zebrafish; tumor xenograft; patient-derived xenograft
资金
- Italian Ministry of Education, University and Research MIUR [PRIN 2017Z3N3YC]
- Neuroendocrine Tumor Research Foundation
Neuroendocrine tumors (NETs) are a class of rare and heterogeneous neoplasms that originate from the neuroendocrine system. In several cases, these neoplasms can release bioactive hormones leading to characteristic clinical syndromes and hormonal dysregulations with detrimental impact on the quality of life and survival of these patients. Only few animal models are currently available to investigate pathogenesis, progression and functional syndromes in NETs and to identify new therapeutic strategies. The tropical teleost zebrafish (Danio rerio) is a popular vertebrate model system that offers unique advantages for the study of several biological processes, ranging from embryonic development to human diseases such as cancer. In this review, we summarize recent advances on zebrafish models for NET preclinical research that take advantage of modern genetic and transplantable technologies. In the future, these tools may have a role in the treatment decision-making and tertiary prevention of NETs.
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