Development of a Novel Molecularly Imprinted Overoxidized Polypyrrole Electrode for the Determination of Sulfasalazine

A novel molecularly imprinted overoxidized polypyrrole electrode was produced for the determination of sulfasalazine (SSZ). The electrode was attained by electropolymerization of pyrrole onto a pencil graphite electrode by cyclic voltammetry. The SSZ was penetrated into the structure during the process. Differential pulse voltammetry was used to determine performance of imprinted (MIP) and non-imprinted (NIP) electrodes. The linear range was attained in the range between 1.0 to 10.0 ppm of SSZ (R-2=0.9993) with a detection limit of 0.265 ppm. The developed MIP electrode and analysis method are suitable for analysis of SSZ with reproducible response and precision in real samples.