期刊
DYES AND PIGMENTS
卷 179, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.dyepig.2020.108387
关键词
Mitochondrial-targeted; NIR; Large Stokes shift; HClO; Bioimaging
资金
- National Natural Science Foundation of China [21672131, 21775096]
- One hundred people plan of Shanxi Province
- Shanxi Province1331 project key innovation team construction plan cultivation team [2018-CT-1]
- 2018 Xiangyuan County Solid Waste Comprehensive Utilization Science and Technology Project [2018XYSDJS-05]
- Shanxi Province Foundation for Returness [2017026]
- Shanxi Collaborative Innovation Center of High Value-added Utilization of Coal-related Wastes [2015-10-B3]
- Shanxi Province Foundation for Selected [2019]
- Innovative Talents of Higher Education Institutions of Shanxi, Scientific and Technological Innovation Programs of Higher Education Institutions in Shanxi [2019L0031]
- Key R&D Program of Shanxi Province [201903D421069]
- Shanxi Province Science Foundation [201901D111015]
- China Institute for Radiation Production, Scientific and Technological Innovation Programs of Higher Education Institutions in Shanxi
- Scientific Instrument Center of Shanxi University [201512]
Hypochlorous acid (HClO) as a reactive oxygen species (ROS) played an important role in many pathological and physiological processes. HClO could kill invading pathogens and bacteria in the immune system. But excessive concentrations of HClO may cause many diseases. Near-infrared fluorescent probes have strong tissue penetrating ability, low autofluorescence interference, and broad application prospects in the field of fluorescence imaging research. In this work, we synthesized a new near-infrared (670 nm) dual-mode fluorescent dye NSSN based on the benzothiazole framework for the visual detection of HClO. The NSSN had a large Stokes shift (220 nm), good selectivity, ratiometric near-infrared and low detection limit (0.13 mu M). In addition, NSSN could achieve mitochondrial target detection of HClO in HeLa cells, also HClO could be visually detected in nude mice by NSSN. Thus NSSN is expected to be used in the early diagnosis of HClO.
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