期刊
DRUG TESTING AND ANALYSIS
卷 13, 期 5, 页码 944-952出版社
WILEY
DOI: 10.1002/dta.2894
关键词
cocaine; Raman spectroscopy; SERS; illicit drug analysis; oral fluid
资金
- Australian Government Research Training Program Scholarship
- Integrated Device for End-User Analysis at Low Levels ARC Research Hub
This study compared seven commercial SERS substrates for the analysis of cocaine, with substrate B providing the best enhancement of cocaine bands. It was shown that SERS is an ideal method for the rapid onsite analysis of illicit drugs in oral fluid, with potential future applications.
The use of illicit drugs across the world causes issues for users, healthcare workers and the public. Therefore, rapid and reliable onsite testing methods to detect these drugs are required. In this study, seven commercial surface-enhanced Raman spectroscopy (SERS) substrates A-G were compared for the analysis of cocaine. These substrates were compared using scanning electron microscopy to study the surface structure and Raman spectroscopy and to determine if there was any enhancement of the cocaine bands. Substrate B provided the best enhancement of known cocaine vibrational bands, allowing the detection down to concentrations of 1 ng/mL in standards and 10 ng/mL extracted from the oral fluid. The results showed that SERS is an ideal method for future rapid onsite analysis of illicit drugs in oral fluid. Commercial SERS substrates were compared for the analysis of cocaine. Substrate B provided the best result and was further tested with lower concentrations and extracts from the oral fluid. The application to oral fluid testing could prove useful for future onsite analysis.
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