期刊
DRUG DISCOVERY TODAY
卷 25, 期 8, 页码 1444-1452出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2020.06.010
关键词
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资金
- Banque Publique D'investissement (BPI, France)
- ANRT [CIFRE 2014/0359, CIFRE 2016/0747, CIFRE 2013/0364, CIFRE 2015/976]
- Eurostars program [Nanoneck-2 E9309, Nanoglioma E11778]
- Aide a L'innovation Responsible (AIR) Program [A1401025Q]
- Agence Nationale de la Recherche (ANR) Mefisto
- Nomis Foundation
- Paris Region Entreprise
- French Research Tax Credit Program (Credit d'Impot Recherche)
- University Paris 6
- University Paris 11
- Paris Biotech Sante
Magnetotactic bacteria (MTB) synthesize iron oxide (Fe3O4) nanoparticles (NPs), called magnetosomes, with large sizes leading to a ferrimagnetic behavior and a stable magnetic moment at physiological temperature, a chain structure that prevents NP aggregation and promotes uniform NP distribution, and a mineral core of magnetite/maghemite composition, which can be stabilized by an organic coating. Such properties can favor magnetosome administration to humans under certain optimized non-toxic conditions of fabrication. In this review, I describe the fabrication methods, physico-chemical properties, and the anti-tumor activity of different types of MTB/magnetosome preparations, highlighting the bio-compatibility and excellent anti-tumor activity of purified non-pyrogenic magnetosome minerals stabilized by a synthetic chemical compound.
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