期刊
DISEASE MODELS & MECHANISMS
卷 13, 期 8, 页码 -出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dmm.044412
关键词
Maz; Sfrp2; Wnt pathway; Eye; CNV 16p11.2
资金
- National Eye Institute [R21EY027427]
- Retina Research Foundation
- National Institute of Kidney and Digestive Diseases [1R01DK078121, T32DK007763]
- Eunice Kennedy Shriver National Institute of Child Health and Human Development [1U54HD100549-01, 1R01HD095341, 5P01HD087157]
- Frederick J. and Theresa Dow Wallace Fund of the New York Community Trust
Wnt/beta-catenin signaling has an essential role in eye development. Faulty regulation of this pathway results in ocular malformations, owing to defects in cell-fate determination and differentiation. Herein, we show that disruption of Maz, the gene encoding Myc-associated zinc-finger transcription factor, produces developmental eye defects in mice and humans. Expression of key genes involved in the Wnt cascade, Sfrp2, Wnt2b and Fzd4, was significantly increased in mice with targeted inactivation of Maz, resulting in abnormal peripheral eye formation with reduced proliferation of the progenitor cells in the region. Paradoxically, the Wnt reporter TCF-Lef1 displayed a significant downregulation in Maz-deficient eyes. Molecular analysis indicates that Maz is necessary for the activation of the Wnt/beta-catenin pathway and participates in the network controlling ciliary margin patterning. Copy-number variations and single-nucleotide variants of MAZ were identified in humans that result in abnormal ocular development. The data support MAZ as a key contributor to the eye comorbidities associated with chromosome 16p11.2 copy-number variants and as a transcriptional regulator of ocular development.
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