期刊
CIRCULATION RESEARCH
卷 118, 期 11, 页码 1786-1807出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/CIRCRESAHA.115.306885
关键词
adipokines; adipose tissue; atherosclerosis; myocardial infarction; obesity
资金
- NHLBI NIH HHS [R01 HL114675, P01 HL081587, R01 HL131006, R01 HL126141] Funding Source: Medline
- NIA NIH HHS [R21 AG052160] Funding Source: Medline
Obesity is causally linked with the development of cardiovascular disorders. Accumulating evidence indicates that cardiovascular disease is the collateral damage of obesity-driven adipose tissue dysfunction that promotes a chronic inflammatory state within the organism. Adipose tissues secrete bioactive substances, referred to as adipokines, which largely function as modulators of inflammation. The microenvironment of adipose tissue will affect the adipokine secretome, having actions on remote tissues. Obesity typically leads to the upregulation of proinflammatory adipokines and the downregulation of anti-inflammatory adipokines, thereby contributing to the pathogenesis of cardiovascular diseases. In this review, we focus on the microenvironment of adipose tissue and how it influences cardiovascular disorders, including atherosclerosis and ischemic heart diseases, through the systemic actions of adipokines.
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