期刊
CIRCULATION RESEARCH
卷 119, 期 12, 页码 1286-1295出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/CIRCRESAHA.116.309301
关键词
chemokines; cytokines; immune system; lymphocytes; venous thrombosis
资金
- German Research Foundation (Deutsche Forschungsgemeinschaft) [WE 4361/4-1]
- German Federal Ministry of Education and Research (Bundesministerium fur Bildung und Forschung) [01EO1003]
Rationale: Immune cells play an important role during the generation and resolution of thrombosis. T cells are powerful regulators of immune and nonimmune cell function, however, their role in sterile inflammation in venous thrombosis has not been systematically examined. Objective: This study investigated the recruitment, activation, and inflammatory activity of T cells in deep vein thrombosis and its consequences for venous thrombus resolution. Methods and Results: CD4(+) and CD8(+) T cells infiltrate the thrombus and vein wall rapidly on deep vein thrombosis induction and remain in the tissue throughout the thrombus resolution. In the vein wall, recruited T cells largely consist of effector-memory T (T-EM) cells. Using T-cell receptor transgenic reporter mice, we demonstrate that deep vein thrombosis-recruited T-EM receive an immediate antigen-independent activation and produce IFN-gamma (interferon) in situ. Mapping inflammatory conditions in the thrombotic vein, we identify a set of deep vein thrombosis upregulated cytokines and chemokines that synergize to induce antigen-independent IFN-gamma production in CD4(+) and CD8(+) T-EM cells. Reducing the number of T-EM cells through a depletion recovery procedure, we show that intravenous T-EM activation determines neutrophil and monocyte recruitment and delays thrombus neovascularization and resolution. Examining T-cell recruitment in human venous stasis, we show that superficial varicose veins preferentially contain activated memory T cells. Conclusions: T-EM orchestrate the inflammatory response in venous thrombosis affecting thrombus resolution.
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