期刊
BLOOD REVIEWS
卷 29, 期 1, 页码 17-24出版社
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.blre.2014.09.003
关键词
Fibrinolysis; Thrombosis; Coagulation; Fibrin(ogen); Hemostasis
类别
资金
- National Institutes of Health [R01 HL042493, R01 HL090895]
- March of Dimes [FY12-356]
- Qatar Research Foundation [NPRP5-932-3-208, NPRP6-736-3-187]
Fibrin plays an essential role in hemostasis as both the primary product of the coagulation cascade and the ultimate substrate for fibrinolysis. Fibrinolysis efficiency is greatly influenced by clot structure, fibrinogen isoforms and polymorphisms, the rate of thrombin generation, the reactivity of thrombus-associated cells such as platelets, and the overall biochemical environment. Regulation of the fibrinolytic system, like that of the coagulation cascade, is accomplished by a wide array of cofactors, receptors, and inhibitors. Fibrinolytic activity can be generated either on the surface of a fibrin-containing thrombus, or on cells that express profibrinolytic receptors. In a widening spectrum of clinical disorders, acquired and congenital defects in fibrinolysis contribute to disease morbidity, and new assays of global fibrinolysis now have potential predictive value in multiple clinical settings. Here, we summarize the basic elements of the fibrinolytic system, points of interaction with the coagulation pathway, and some recent clinical advances. (C) 2014 Published by Elsevier Ltd.
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