期刊
CIRCULATION RESEARCH
卷 118, 期 8, 页码 1327-1336出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/CIRCRESAHA.116.307709
关键词
blood pressure; bone marrow; dysbiosis; hypertension; microbiota
资金
- NCATS NIH HHS [UL1TR001427, UL1 TR001427] Funding Source: Medline
- NHLBI NIH HHS [R01 HL056921, HL102033, R01 HL033610, HL33610, 5UM1HL087366, R37 HL033610, R01 HL132448, R01 HL102033, UM1 HL087366, HL56921] Funding Source: Medline
Hypertension is the most prevalent modifiable risk factor for cardiovascular disease and disorders directly influencing cardiovascular disease morbidity and mortality, such as diabetes mellitus, chronic kidney disease, obstructive sleep apnea, etc. Despite aggressive attempts to influence lifestyle modifications and advances in pharmacotherapeutics, a large percentage of patients still do not achieve recommended blood pressure control worldwide. Thus, we think that mechanism-based novel strategies should be considered to significantly improve control and management of hypertension. The overall objective of this review is to summarize implications of peripheral- and neuroinflammation as well as the autonomic nervous system-bone marrow communication in hematopoietic cell homeostasis and their impact on hypertension pathophysiology. In addition, we discuss the novel and emerging field of intestinal microbiota and roles of gut permeability and dysbiosis in cardiovascular disease and hypertension. Finally, we propose a brain-gut-bone marrow triangular interaction hypothesis and discuss its potential in the development of novel therapies for hypertension.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据