期刊
DEVELOPMENT GROWTH & DIFFERENTIATION
卷 62, 期 6, 页码 407-422出版社
WILEY
DOI: 10.1111/dgd.12688
关键词
piRNA; PIWI; planarian; stem cell; transposon
资金
- [17K07421]
- [19K16149]
Planarians have a remarkable regenerative ability owing to their adult pluripotent stem cells (aPSCs), which are called neoblasts. Planarians maintain a considerable number of neoblasts throughout their adulthood to supply differentiated cells for the maintenance of tissue homeostasis and asexual reproduction (fission followed by regeneration). Thus, planarians serve as a good model to study the regulatory mechanisms of in vivo aPSCs. In asexually reproducing invertebrates, such as sponge, Hydra, and planaria,piwifamily genes are the markers most commonly expressed in aPSCs. Whilepiwifamily genes are known as guardians against transposable elements in the germline cells of animals that only sexually propagate, their functions in the aPSC system have remained elusive. In this review, we introduce recent knowledge on the PIWI family proteins in the aPSC system in planarians and other organisms and discuss how PIWI family proteins contribute to the regulation of the aPSC system.
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