期刊
DENTAL MATERIALS JOURNAL
卷 39, 期 4, 页码 670-677出版社
JAPANESE SOC DENTAL MATERIALS DEVICES
DOI: 10.4012/dmj.2019-187
关键词
Hindlimb-unloading; Femur; Bone quality; Biological apatite crystallite alignment; Bone mineral density (BMD)
资金
- MEXT of Japan
- [17K11808]
- [18K09643]
The aim of this study was clarify the effects of reducing various functional pressures essential for the maintenance of bone homeostasis. Femoral bone mineral density (BMD) and biological apatite (BAp) crystallite alignment were measured in conventionally reared and hindlimb-unloaded mice. The femur was divided into 10 equal segments perpendicular to the longitudinal axis of the bone and measurements were performed on the cortical bone in the five segments closest to the midpoint of the femur. Significantly lower BMD and BAp alignment in the longitudinal (Z-axis) direction were observed in the hindlimb-unloaded group. The present findings suggest that unloading by tail suspension significantly decreases not only mouse femoral bone mass but also BAp crystallite alignment, although minimal uniaxial preferential alignment is retained.
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