期刊
CIRCULATION JOURNAL
卷 80, 期 7, 页码 1539-+出版社
JAPANESE CIRCULATION SOC
DOI: 10.1253/circj.CJ-16-0183
关键词
Acute myocardial infarction; Percutaneous coronary intervention; Prognosis; Ventricular tachycardia; Ventricular fibrillation
资金
- Japanese Ministry of Education, Culture, Sports, Science and Technology, Tokyo, Japan [19590816, 19390215, 25461055]
- Grants-in-Aid for Scientific Research [25461055] Funding Source: KAKEN
Background: The aim of this study was to investigate the prognostic impact of acute-phase ventricular tachycardia and fibrillation (VT/VF) on ST-segment elevation myocardial infarction (STEMI) patients in the percutaneous coronary intervention (PCI) era. Methods and Results: Using the database of the Osaka Acute Coronary Insufficiency Study (OACIS), we studied 4,283 consecutive patients with STEMI who were hospitalized within 12 h of STEMI onset and underwent emergency PCI. Acute-phase VT/VF, defined as >= 3 consecutive ventricular premature complexes and/or VF within the 1st week of hospitalization, occurred in 997 (23.3%) patients. In-hospital mortality risk was significantly higher in patients with acute-phase VT/VF than inthose without (14.6% vs. 4.3%, adjusted hazard ratio (HR) 1.83, P=0.0013). Among patients discharged alive, 5-year mortality rates were comparable between patients with and without acute-phase VT/VF. Subgroup analysis showed that acute-phase VT/VF was associated with increased 5-year mortality after discharge in high-risk patients (GRACE Risk Score >= 115; adjusted HR 1.60, P=0.043), but not in intermediate-or low-risk patients. Conclusions: Even in the PCI era, acute-phase VT/VF was associated with higher in-hospital deaths of STEMI patients. However, the 5-year prognostic impact of acute-phase VT/VF was limited to high-risk patients.
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