期刊
CIRCULATION JOURNAL
卷 80, 期 8, 页码 1857-+出版社
JAPANESE CIRCULATION SOC
DOI: 10.1253/circj.CJ-16-0030
关键词
Albuminuria; Chronic kidney disease; Epidemiology; Kidney dysfunction; Serum uric acid
资金
- Ministry of Education, Culture, Sports, Science and Technology of Japan [25253048, 25460758, 26350895, 26460748, 15K09267, 15K08738, 15K09835]
- Ministry of Health, Labour and Welfare of Japan [H25-Junkankitou [Seishuu]-Sitei-022, H26-Junkankitou [Seisaku]-Ippan-001, H26-Nanchitou [Nan]-Ippan-042, H27-Shokuhin-[Sitei]-017]
- Japan Agency for Medical Research and Development (AMED) [15dk0207003 h0003, 15dk0207018 h0001, 15ek0210001 h0003, 15ek0210004s0102, 15 gm0610007 h0203]
- Grants-in-Aid for Scientific Research [15K08738, 26460748, 16H02644] Funding Source: KAKEN
Background: Growing evidence suggests that high serum uric acid (SUA) levels are causally related to increased risk of chronic kidney disease (CKD). However, few studies have investigated the influence of elevated SUA levels on the incidence of kidney dysfunction and albuminuria separately in community-based populations. Methods and Results: A total of 2,059 community-dwelling Japanese subjects aged >= 40 years without CKD were followed for 5 years. CKD was defined as kidney dysfunction (estimated glomerular filtration rate <60 ml/min/1.73 m(2)) or albuminuria (urine albumin-creatinine ratio >= 30 mg/g). The odds ratio (OR) for the development of CKD was estimated according to quartiles of SUA (<= 4.0, 4.1-4.9, 5.0-5.8, and >= 5.9 mg/dl). During the follow-up, 396 subjects developed CKD, of whom 125 had kidney dysfunction and 312 had albuminuria. The multivariable-adjusted risk of developing CKD increased with higher SUA levels (OR 1.00 [reference] for <= 4.0, 1.21 [95% confidence interval, 0.84-1.74] for 4.1-4.9, 1.47 [1.01-2.17] for 5.0-5.8, and 2.10 [1.37-3.23] for SUA >= 5.9 mg/dl, respectively). Similarly, there were positive associations between SUA level and the adjusted risk of developing kidney dysfunction (OR 1.00 [reference], 2.30 [1.10-4.82], 2.81 [1.34-5.88], and 3.73 [1.65-8.44]) and albuminuria (1.00 [reference], 1.12 [0.76-1.65], 1.35 [0.90-2.03], and 1.81 [1.14-2.87], respectively). Conclusions: Higher SUA levels were a significant risk factor for the development of both kidney dysfunction and albuminuria in a general Japanese population.
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