期刊
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
卷 22, 期 5, 页码 562-570出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1389201021666200807113723
关键词
Panax ginseng; ginsenoside; genomics; transcriptomics; proteomics; metabolomics
资金
- Fundamental Research Funds for the Central Public Welfare Research Institutes [ZXKT17027]
- National Key Research and Development Program of China [2017YFC1702100]
- Funding for Basic Scientific Research Business of China Academy of Chinese Medical Sciences [ZZ13-YQ-047]
- National Science and Technology Major Project for Significant New Drugs Development [2019ZX09201005-002-002]
- NSFC [81891011]
- TCM One Belt and One Road Project of CACMS [GH201915]
Ginseng, known as the king of herbs, has been used as an important traditional medicine for thousands of years. Ginsenosides, bioactive compounds of ginseng, have posed challenges for research and development due to their complexity. In recent years, the emergence of new biological research tools, particularly omics and bioinformatic tools, has become a major trend in ginseng research.
Ginseng, also known as the king of herbs, has been regarded as an important traditional medicine for several millennia. Ginsenosides, a group of triterpenoid saponins, have been characterized as bioactive compounds of ginseng. The complexity of ginsenosides hindered ginseng research and development both in cultivation and clinical research. Therefore, deciphering the ginsenoside biosynthesis pathway has been a focus of interest for researchers worldwide. The new emergence of biological research tools consisting of omics and bioinformatic tools or computational biology tools are the research trend in the new century. Ginseng is one of the main subjects analyzed using these new quantification tools, including tools of genomics, transcriptomics, and proteomics. Here, we review the current progress of ginseng omics research and provide results for the ginsenoside biosynthesis pathway. Organization and expression of the entire pathway, including the upstream MVA pathway, the cyclization of ginsenoside precursors, and the glycosylation process, are illustrated. Regulatory gene families such as transcriptional factors and transporters are also discussed in this review.
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