期刊
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
卷 22, 期 1, 页码 182-190出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1389201021666200602134054
关键词
Self-Assembly; oleophilic nanospheres; polyprotein; ANIAE; thermally controlled release; assembled biomaterials
资金
- Pearl River Talents Scheme Fund (overseas), Guangdong Human Resources and Social Security Department, Guangdong Government [CANHum (2017)3]
- Guangdong Province Foundation and Applied Basic Research Special Fund for PhD Research Project Initiation
- Guangdong Science and Technology Department, Guangdong Government [CANSci (2017)1935]
- National Natural Science Foundation of China [81473155]
- Science and Technology Plan Projects of Guangdong Province, Guangdong Science and Technology Department, Guangdong Government [2015B020232010]
This study presents a multifunctional approach for pharmaceutical management, utilizing the ANIAE technique to assemble nanospheres in one step using polyprotein microspheres. The results demonstrate a versatile and universal solution for insoluble active ingredients.
Background: The administration of many pharmaceutical active ingredients is often performed by the injection of an aqueous-based solution. Numerous active ingredients are however, insoluble in water, which complicates their administration and restricts their efficacy. Objective: The current solutions are hindered by both, a time-consuming manufacturing process and unsuitability for hydrophilic and hydrophobic materials. Methods: Emulsions of oleophilic active ingredients and polyprotein microspheres are an important step to overcome insolubility issues. Results: Polyprotein microspheres offer a versatile modifiable morphology, thermal responsivity, and size variation, which allows for the protection and release of assembled biomaterials. In addition, nanospheres present promising cell phagocytosis outcomes in vivo. Conclusion: In this research, a reproducible multifunctional approach, to assemble nanospheres in one step, using a technique termed automatic nanoscalar interfacial alternation in emulsion (ANIAE) was developed, incorporating a thermally controlled release mechanism for the assembled target active ingredients. These results demonstrate a viable, universal, multifunctional principal for the pharmaceutical industry.
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