期刊
CURRENT OPINION IN STRUCTURAL BIOLOGY
卷 62, 期 -, 页码 22-30出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2019.11.004
关键词
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资金
- European Research Council (ERC-2017-AdG) [788143-RECGLYC-ANMR]
- Instituto de Salud Carlos III of Spain, ISCIII [PRB3 IPT17/0019]
- Agencia Estatal Investigacio'n of Spain, AEI [CTQ2015-64597-C2-1-P, RTI2018-094751-B-C21]
- Agencia Estatal Investigacio'n of Spain, AEI (FPU)
- Severo Ochoa Excellence Accreditation [SEV-2016-0644]
Carbohydrate molecules are essential actors in key biological events, being involved as recognition points for cell-cell and cell-matrix interactions related to health and disease. Despite outstanding advances in cryoEM, X-ray crystallography and NMR still remain the most employed techniques to unravel their conformational features and to describe the structural details of their interactions with biomolecular receptors. Given the intrinsic flexibility of saccharides, NMR methods are of paramount importance to deduce the extent of motion around their glycosidic linkages and to explore their receptor-bound conformations. We herein present our particular view on the latest advances in NMR methodologies that are permitting to magnify their applications for deducing glycan conformation and dynamics and understanding the recognition events in which there are involved.
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