期刊
CURRENT OPINION IN NEUROBIOLOGY
卷 62, 期 -, 页码 133-140出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.conb.2020.03.006
关键词
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资金
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) [K01 DK113047]
- National Heart, Lung, and Blood Institute (NHLBI) [R01 HL150449]
- NIH Director's New Innovator Award [DP2 HL151354]
- China Scholarship Council (CSC) -Yale World Scholars Program in Biomedical Sciences
Our understanding of the gut system has been revolutionized over the past decade, in particular regarding its role in immune control and psychological regulation. The vagus nerve is a crucial link between gut and brain, transmitting diverse gut-derived signals, and has been implicated in many gastrointestinal, neurological, and immunological disorders. Using state-of-the-art technologies including single-cell genomic analysis, real-time neural activity recording, transsynaptic tracing, and electron microscopy, novel physiological functions of vagal gut afferents have been uncovered, and new gut-to-brain pathways have been revealed. Here, we review the most recent findings on vagal sensory neurons and the gutbrain signaling, focusing on the anatomical basis and the underlying molecular and cellular mechanisms. Such new discoveries explain some of the old puzzling problems and also raise new questions in this exciting and rapidly growing field.
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