期刊
CURRENT OPINION IN COLLOID & INTERFACE SCIENCE
卷 47, 期 -, 页码 111-117出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.cocis.2019.12.010
关键词
Atomic force microscopy; Force; Single-molecule force spectroscopy; Single-cell force spectroscopy; Microbial pathogens; Infection; Cell adhesion
资金
- European Research Council (ERC) under the European Union [693630]
- National Fund for Scientific Research (FNRS)
- FNRS-WELBIO [WELBIO-CR2015A-05]
- Research Department of the Communaute francaise de Belgique (Concerted Research Action)
Microbes have evolved sophisticated strategies to colonize biotic and abiotic surfaces. Forces play a central role in microbial cell adhesion processes, yet until recently these were not accessible to study at the molecular scale. Unlike traditional assays, atomic force microscopy (AFM) is capable to study forces in single cell surface molecules and appendages, in their biologically relevant conformation and environment. Recent AFM investigations have demonstrated that bacterial pili exhibit a variety of mechanical responses upon contact with surfaces and that cell surface adhesion proteins behave as force-sensitive switches, two phenomena that play critical roles in cell adhesion and biofilm formation. AFM has also enabled to assess the efficiency of sugars, peptides, and antibodies in blocking cell adhesion, opening up new avenues for the development of antiadhesion therapies against pathogens.
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