期刊
CURRENT OPINION IN CHEMICAL BIOLOGY
卷 56, 期 -, 页码 23-27出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2019.10.004
关键词
Bioinorganic chemistry; Medicinal inorganic chemistry; Metals in medicine; Photodynamic therapy; Photosensitizer
资金
- ERC Consolidator Grant PhotoMedMet [GA 681679]
- program Investissements d'Avenir
- ANR [ANR-10-IDEX-0001-02 PSL]
- University of North Carolina at Greensboro
- University of Texas at Arlington
- National Cancer Institute of the National Institutes of Health [R01CA222227]
- Theralase Technologies Inc. (Toronto, Ontario, Canada)
- NATIONAL CANCER INSTITUTE [R01CA222227] Funding Source: NIH RePORTER
Photodynamic therapy (PDT) is an approved medical technique to treat certain forms of cancer. It has been used to complement traditional anticancer modalities such as surgery, chemotherapy or radiotherapy, and in certain cases, to replace these treatments. One critical parameter of PDT is the photosensitizer (PS); historically, a purely organic macrocyclic tetrapyrrole-based structure. This short review surveys two recent clinical examples of metal complexes, namely TOOKAD (R)-Soluble and TLD-1433, which have ideal photophysical properties to act as PDT PSs. We highlight the important role played by the metal ions in the PS for PDT activity.
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