4.5 Review

Inter-organelle lipid transfer: a channel model for Vps13 and chorein-N motif proteins

期刊

CURRENT OPINION IN CELL BIOLOGY
卷 65, 期 -, 页码 66-71

出版社

CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2020.02.008

关键词

Membrane contact sites; Lipid transfer proteins; Chorein_N motif

资金

  1. NIGMS [R35 GM131715]

向作者/读者索取更多资源

Membrane contact sites, where two organelles are in close proximity, are critical regulators of cellular membrane homeostasis, with roles in signaling, lipid metabolism, and ion dynamics. A growing catalog of specialized lipid transfer proteins carry out lipid exchange at these sites. Currently characterized eukaryotic lipid transport proteins are shuttles that typically extract a single lipid from the membrane of the donor organelle, solubilize it during transport through the cytosol, and deposit it in the acceptor organelle membrane. Here, we highlight the recently identified chorein_N family of lipid transporters, including the Vps13 proteins and the autophagy protein Atg2. These are elongated proteins that, distinct from previously characterized transport proteins, bind tens of lipids at once. They feature an extended channel, most likely lined with hydrophobic residues. We discuss the possibility that they are not shuttles but instead are bridges between membranes, with lipids traversing the cytosol via the hydrophobic channel.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.5
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据