Synthesis, admetSAR Predictions, DPPH Radical Scavenging Activity, and Potent Anti-mycobacterial Studies of Hydrazones of Substituted 4-(anilino methyl) benzohydrazides (Part 2)

Background: For the past several decades, the presence of tuberculosis (TB) is being remarked as the most common infectious disease leading to mortality. Objective: Hydrazone containing azometine group (-NHN=CH-) compounds have been reported for a broad range of bioactivities such as antiplatelet, analgesic, anti-inflammatory, anticonvulsant, antidepressant, antimalarial, vasodilator, antiviral, and antimicrobial, etc. Methods: For the synthesis of compounds (4a-4d) and (6a-6e), aromatic amines were treated with methyl terephthalaldehydate in methanol, giving Schiff's bases, followed by reductive amination and further treatment with hydrazine hydrate gave acid hydrazides (4a-4d). These acid hydrazides were then treated with different aromatic aldehydes to yield hydrazones (6a-6d). All the synthesized compounds were subjected to FT-IR, NMR, and UV spectroscopic characterization. Results: Compounds (4a-4d) and (6a-6e) were found to have highly potent activity against Myco-bacteria tuberculosis (Vaccine strain, H37 RV strains): ATCC No-27294 (MIC:1.6-6.25 mu g/mL) than standard anti-TB drugs. The compounds exhibited good radical scavenging potentials(0-69.2%), as checked from DPPH protocol. All compounds also demonstrated good in-silico AD-MET results. Conclusion: The current study revealed promising in vitro anti-tuberculosis and anti-oxidant pro-files of hydrazide-hydrazone analogues.

Automated summary

This study synthesized a series of hydrazone-containing compounds with potent activity against Mycobacterium tuberculosis. The compounds also showed good radical scavenging potentials and in-silico AD-MET results.