期刊
CURRENT APPLIED PHYSICS
卷 40, 期 -, 页码 30-42出版社
ELSEVIER
DOI: 10.1016/j.cap.2020.06.002
关键词
Microsphere; Gallic acid; Controlled release; Polyphenols; Cancer
资金
- Gazi University Scientific Research Projects Unit (BAP) [47/2017/13]
This study focused on the formation of GA-containing microspheres using NaAlg and the investigation of their release profile. The microspheres exhibited a controlled release profile and effectively retained the antioxidant and anticancer activities of GA. Further studies are needed to explore the potential application of GA-loaded NaAlg microspheres in adjunct and complementary therapies.
Polyphenols found in fruits and vegetables are of great interest due to their health benefits. Gallic acid (GA) is an antioxidant with cytotoxic effects. Microspheres are drug carrier systems, where the active substance is trapped in matrix. A controlled release profile is aimed at the target region by preserving the loss of substance and activity. In this study, GA containing microspheres were formed with sodium alginate (NaAlg) in formulations with different ratios. The arrest efficiencies ranged between 11.26 and 72.64%. Release studies were performed at pH 7.4. Optimum conditions were determined as GA/NaAlg ratio 1/8. The microspheres were found to arrest GA and exhibit a controlled release profile. Microspheres were characterized by scanning electron microscope (SEM), differential scanning calorimetry (DSC), X-Ray diffraction (XRD), Fourier transform infrared spectrometer (FTIR) analysis. GA retained its antioxidant activity determined by DPPH (2,2-diphenyl-1-picrylhydrazyl) method and anticancer activity on Caco-2 cells. Further studies are necessary on GA-loaded NaAlg microspheres which have high potential to be used in adjunct and complementary therapies.
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