期刊
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
卷 61, 期 16, 页码 2705-2718出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/10408398.2020.1784839
关键词
Biomarkers; fatty acids; meta-analysis; systematic review; type 2 diabetes mellitus
资金
- National Natural Science Foundation of China [81502798]
- Natural Science Foundation of Guangdong Province, China [2015A030310399]
- Basic and Applied Basic Research Foundation of Guangdong Province [2019A1515110163]
- Foundation of Bureau of Science and Technology of Foshan City [1920001000294]
This study found divergent associations of different types of fatty acids with type 2 diabetes mellitus. Some fatty acids showed a negative correlation with the risk of T2DM, while others showed a positive correlation.
We aimed to quantify and generate comprehensive evidence on the associations of different fatty acids (FAs) with the risk of type 2 diabetes mellitus (T2DM). PubMed, MEDLINE, and Embase were searched for prospective cohort studies that examined the association between FA biomarkers and the risk of T2DM published before 18 May 2020. Random-effects meta-analyses of the effects of FA concentration on T2DM were performed. Thirty-three studies involving 95,810 adults (19,904 cases) were included. Divergent associations of different types of FAs with type 2 diabetes were observed. The pooled relative risk (RRs) of T2DM comparing the top versus the bottom tertile of saturated FAs (C14:0, C16:0, C18:0, total saturated FAs), monounsaturated FA (C16:1 n-7), polyunsaturated FA (C20:3 n-6, C22:4 n-6), and Delta-6-desaturase activities ranged from 1.19 to 1.80. Interestingly, unlike previous studies, we found a negative correlation between odd-chain saturated FAs (C15:0, C17:0), trans-FAs (trans-C16:1 n-7), total n-6, Delta-5-desaturase activities and risk of T2DM. The pooled RRs of T2DM comparing the top versus the bottom tertile of these FAs ranged from 0.62 to 0.78. No associations with T2DM were observed for the other FAs. Considerable heterogeneity was observed in our study, and no definitive conclusions can be made until further investigation has been carried out.
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