Magnetic Nanoparticles Based Solid Phase Extraction Methods for the Determination of Trace Elements

The past three decades has seen significant advancements in instrumental detection techniques for both organic and inorganic analytes, leading to more accurate and precise measurements. The relevance of sample preparation prior to instrumental reading cannot be underestimated, and this area has also seen major improvements, with solid phase extraction (SPE) and its miniaturized version (solid phase microextraction, SPME) serving as an efficient clean-up and preconcentration method for analytes. Magnetic nanoparticles (MNPs) belong to the new generation of sorbents, and their characteristic small size and easy manipulation under magnetic field make them ideal materials for extraction of several analytes. This review presents the basic principles of SPE and SPME, and lays more emphasis on different types of MNPs that have been used as efficient separation and preconcentration tools. In addition, application of MNPs for the determination of trace elements in environmental, biological and food samples are well documented in this review.

Automated summary

Significant advancements in instrumental detection techniques have been made in the past three decades, leading to more accurate measurements of organic and inorganic analytes. The importance of sample preparation before instrumental reading cannot be underestimated, and solid phase extraction (SPE) and solid phase microextraction (SPME) have emerged as efficient methods for clean-up and preconcentration. Magnetic nanoparticles (MNPs) have become ideal materials for analyte extraction due to their small size and easy manipulation under a magnetic field. This review focuses on the principles of SPE and SPME, and highlights the different types of MNPs that have been used for separation and preconcentration. The application of MNPs in the determination of trace elements in environmental, biological, and food samples is also discussed.