期刊
CIRCULATION
卷 134, 期 2, 页码 101-+出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/CIRCULATIONAHA.115.019307
关键词
epidemiology; heart defects, congenital; population
资金
- Canadian Institute of Health Research
- Heart and Stroke Foundation of Canada
- Fonds de la recherche en sante du Quebec
- National Heart, Lung, and Blood Institute [HH-SN268201300046C, HHSN268201300047C, HHSN268201300049C]
- National Institute on Minority Health and Health Disparities
- National Center for Complementary and Alternative Medicine [1U01AT006239-01]
- National Institute on Minority Health and Health Disparities [P60MD002249-01]
- Arkansas Biosciences Institute
Background: Because of advancements in care, there has been a decline in mortality from congenital heart defects (CHDs) over the past several decades. However, there are no current empirical data documenting the number of people living with CHDs in the United States. Our aim was to estimate the CHD prevalence across all age groups in the United States in the year 2010. Methods: The age-, sex-, and severity-specific observed prevalence of CHDs in Quebec, Canada, in the year 2010 was assumed to equal the CHD prevalence in the non-Hispanic white population in the United States in 2010. A race-ethnicity adjustment factor, reflecting differential survival between racial-ethnic groups through 5 years of age for individuals with a CHD and that in the general US population, was applied to the estimated non-Hispanic white rates to derive CHD prevalence estimates among US non-Hispanic blacks and Hispanics. Confidence intervals for the estimated CHD prevalence rates and case counts were derived from a combination of Taylor series approximations and Monte Carlo simulation. Results: We estimated that approximate to 2.4 million people (1.4 million adults, 1 million children) were living with CHDs in the United States in 2010. Nearly 300 000 of these individuals had severe CHDs. Conclusions: Our estimates highlight the need for 2 important efforts: planning for health services delivery to meet the needs of the growing population of adults with CHD and the development of surveillance data across the life span to provide empirical estimates of the prevalence of CHD across all age groups in the United States.
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