期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 190, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.colsurfb.2020.110895
关键词
Poly-L-lysine dendrigraft; Polyamine-salt aggregates; Size pH-switchable supraparticles; Trypsin-triggered release; Multistage drug release
资金
- Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET, Argentina) [PIP 0370]
- Agencia Nacional de Promocion Cientifica y Tecnologica (ANPCyT) [PICT 2016-1680, 2017-1523]
- Austrian Institute of Technology GmbH (AIT-CONICET Partner Group: Exploratory Research for Advanced Technologies in Supramolecular Materials Science) [Exp. 4947/11, 3911]
- Universidad Nacional de La Plata (UNLP)
- CONICET
Multistage delivery systems with size reduction capacity have been proposed as a powerful strategy for improving tissue drug penetration. Here we developed a simple and fast supramolecular approach to construct size-shrinkable polyamine-salt aggregates by ionic cross-linking of biodegradable poly-L-lysine dendrigraft with tripolyphosphate anion. The use of a peptide dendrimer as a nanobuilding block (similar to 7 nm in diameter) allows the formation of supraparticles (SPs) with well-defined dimensions (similar to 200 nm in diameter), narrow size distribution and great capacity to encapsulate different molecules, including chemotherapeutic agents as Curcumin and Doxorubicin. When exposed to slightly acidic environments, the crosslinked matrix is instantaneously disassembled to free dendrimer units. Subsequently, model cargo molecules entrapped in the dendrimer architecture can be released by the action of trypsin enzyme through peptide biodegradation. Therefore, these SPs with proved sequential pH and enzyme-responsiveness could be exploited as nanocarriers in multistage drug delivery systems.
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