期刊
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
卷 598, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.colsurfa.2020.124805
关键词
Flavonoids; Luteolin; Coordination self-assembly; Nanoparticles; Cancer therapy
资金
- National Natural Science Foundation of China [51861145304, 21703252, 21802144]
- Innovation Research Community Science Fund [21821005]
- Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS) [QYZDB-SSW-JSC034]
Utilizing small natural molecules from traditional Chinese medicines is highly promising and advantageous in curing diverse diseases. However, the clinical translation of many of these molecular drugs was hindered due to the vulnerable chemical structure and poor solubility. Herein, we reported a coordination-driven assembly strategy to synchronously enhance the stability and solubility of a typical natural molecular drug (luteolin) through the formation of nanoparticles. The resulting nanoparticles showed much enhanced solubility in physiological environment, broadened absorption spectrum to the near-infrared region, and high stability against oxidation. Intriguingly, the coordinated assembly with ferric ion introduces the supramolecular photothermal effects, enabling the nanoparticles to act as either a chemotherapeutic agent or a photothermal agent. This work represents that the coordination assembly strategy is facile and efficient for design of nanodrugs starting from naturally-derived molecular drugs and greatly enhance their therapeutic efficacy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据