期刊
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
卷 19, 期 7, 页码 503-508出版社
BENTHAM SCIENCE PUBL
DOI: 10.2174/1871527319999200729153907
关键词
Fibroblast growth factor 2; schizophrenia; hyperbilirubinemia; Gunn rat; neuroinflammation; Unconjugated Bilirubin (UCB)
资金
- JSPS KAKENHI, Japan [19K08046, 19K08018]
- Grants-in-Aid for Scientific Research [19K08046] Funding Source: KAKEN
Background: Fibroblast Growth Factor (FGF) 2 (also referred to as basic FGF) is a multi-functional growth factor that plays a pivotal role in the pro-survival, pro-migration and pro-differentiation of neurons. Method: Because alterations in FGF2 levels are suggested to contribute to the pathogenesis of schizophrenia, we investigated serum levels of FGF2 in the Gunn rat, a hyperbilirubinemia animal model of schizophrenic symptoms. Results: The enzyme-linked immunosorbent assay showed that the serum levels of FGF2 in Gunn rats were 5.09 +/- 0.236 pg/mL, while those in the normal strain Wistar rats, serum levels were 11.90 +/- 2.142 pg/mL. The serum FGF2 levels in Gunn rats were significantly lower than those in Wistar rats. We also measured serum levels of Unconjugated Bilirubin (UCB) and found a significant negative correlation between UCB and FGF2 in terms of serum levels in all the rats studied. Conclusion: Since it is known that FGF2 regulates dopaminergic neurons and have anti-neuroinflammatory effects, our finding suggests that low FGF2 levels may contribute to the pathogenesis of schizophrenia, in which imbalanced dopamin-ergic signaling and neuroinflammation are supposed to play certain roles.
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