期刊
CLINICAL NEUROPHYSIOLOGY
卷 131, 期 6, 页码 1174-1179出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.clinph.2020.02.032
关键词
Automatic spike detection; Biomarker; Deep learning; EEG; Interictal epileptiform discharges; Epilepsy
资金
- Henry & Carla Hansen Foundation
- Austrian Research Promotion Agency [864182]
Objective: To validate an artificial intelligence-based computer algorithm for detection of epileptiform EEG discharges (EDs) and subsequent identification of patients with epilepsy. Methods: We developed an algorithm for automatic detection of EDs, based on a novel deep learning method that requires a low amount of labeled EEG data for training. Detected EDs are automatically grouped into clusters, consisting of the same type of EDs, for rapid visual inspection. We validated the algorithm on an independent dataset of 100 patients with sharp transients in their EEG recordings (54 with epilepsy and 46 with non-epileptic paroxysmal events). The diagnostic gold standard was derived from the video-EEG recordings of the patients' habitual events. Results: The algorithm had a sensitivity of 89% for identifying EEGs with EDs recorded from patients with epilepsy, a specificity of 70%, and an overall accuracy of 80%. Conclusions: Automated detection of EDs using an artificial intelligence-based computer algorithm had a high sensitivity. Human (expert) supervision is still necessary for confirming the clusters of detected EDs and for describing clinical correlations. Further studies on different patient populations will be needed to confirm our results. Significance: The automated algorithm we describe here is a useful tool, assisting neurophysiologist in rapid assessment of EEG recordings. (C) 2020 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.
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