期刊
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
卷 16, 期 2, 页码 294-303出版社
AMER SOC NEPHROLOGY
DOI: 10.2215/CJN.15161219
关键词
APOL1; chronic kidney disease; genetic kidney disease; Kidney Genomics Series; APOL1 protein; human; Apolipoprotein L1; HIV-Associated Nephropathy; African Americans; Glomerulosclerosis; Focal Segmental; kidney; hypertension; Genetics; Population; diabetes mellitus
资金
- US Department of Health and Human Services, National Institutes of Health, National Center on Minority Health and Health Disparities [014726, 007092]
Rates of severe kidney disease are higher in Black individuals due to genetic variants in the apoL1 gene, which increase rates of certain kidney diseases such as hypertension-associated ESKD, FSGS, and HIV-associated nephropathy. Clinical issues may arise for nephrologists caring for patients with APOL1 kidney disease.
Rates of many types of severe kidney disease are much higher in Black individuals than most other ethnic groups. Much of this disparity can now be attributed to genetic variants in the apoL1 (APOL1) gene found only in individuals with recent African ancestry. These variants greatly increase rates of hypertension-associated ESKD, FSGS, HIV-associated nephropathy, and other forms of nondiabetic kidney disease. We discuss the population genetics of APOL1 risk variants and the clinical spectrum of APOL1 nephropathy. We then consider clinical issues that arise for the practicing nephrologist caring for the patient who may have APOL1 kidney disease.
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