期刊
CLINICAL INFECTIOUS DISEASES
卷 73, 期 9, 页码 E3102-E3105出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/cid/ciaa1165
关键词
SARS-CoV-2; neurological manifestations; COVID-19; intrathecal synthesis; blood-brain barrier
This study analyzed the cerebrospinal fluid features of 31 COVID-19 patients with neurological complications and found no SARS-CoV-2 RNA or intrathecal IgG synthesis, but observed signs of blood-brain barrier disruption. These results may help improve understanding of SARS-CoV-2 related neuropathogenesis.
This study analyzed the cerebrospinal fluid features of 31 coronavirus disease 2019 (COVID-19) patients with neurological complications. We observed neither severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA in the cerebrospinal fluid, nor intrathecal immunoglobulin G (IgG) synthesis but did observe signs of blood-brain barrier disruption. These results might serve as a basis for a better understanding of SARS-CoV-2 related neuropathogenesis.
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