期刊
CLINICAL INFECTIOUS DISEASES
卷 72, 期 11, 页码 2029-2031出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/cid/ciaa1015
关键词
hepatitis B virus; pregenomic RNA; viral diagnostic assay; quantitative polymerase chain reaction
资金
- Abbott Diagnostics Division Research and Development
The study found that full-length pregenomic RNA is the primary source of circulating HBV RNA in infected patients, clarifying the major identity of HBV RNA species in circulation.
Hepatitis B virus RNA is detectable in the serum of infected patients; however, the RNA species has been questioned. We tested 1827 specimens using a quantitative dual-target quantitative polymerase chain reaction assay and determined that full-length pregenomic RNA is the primary source. 'these results clarify the major identity of circulating HBV RNA species.
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