期刊
CLINICAL INFECTIOUS DISEASES
卷 72, 期 3, 页码 486-489出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/cid/ciaa785
关键词
PrEP; HIV prevention; urine; immunoassay; ELISA
资金
- National Institute of Allergy and Infectious Diseases (USAID)/National Institutes of Health (NIH) [R01AI143340]
- NIH institutional training grant [T32AI007140, T32AI060530]
- Bill & Melinda Gates Foundation [OPP47674]
In order to support PrEP adherence for HIV prevention, new tools are needed, including those that offer real-time feedback. In a large completed PrEP trial, a novel immunoassay measuring adequate urine tenofovir levels predicted HIV protection and demonstrated good sensitivity and specificity for detectable plasma tenofovir.
New tools are needed to support pre-exposure prophylaxis (PrEP) adherence for human immunodeficiency virus (HIV) prevention, including those that enable real-time feedback. In a large, completed PrEP trial, adequate urine tenofovir levels measured using a novel immunoassay predicted HIV protection and showed good sensitivity and specificity for detectable plasma tenofovir.
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