期刊
CLINICAL IMMUNOLOGY
卷 216, 期 -, 页码 -出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.clim.2020.108462
关键词
Myasthenia gravis; AChR-specific T cells; Th1 cells; Th17 cells
类别
资金
- National Natural Science Foundation of China [81620108010, 81873772, 81371386, 81773660, 81971754]
- Clinical Study of 5010 Planned Project from Sun Yat-sen University in China [2010003]
- Guangdong Province Foundation
- Guangdong Science and Technology Department [CANSci (2017)1935]
- Pearl River Talents Scheme Fund from Human Resources and Social Security Department of Guangdong Province [CANHum (2017)3]
- Southern China International Cooperation Base for Early Intervention and Functional Rehabilitation of Neurological Diseases [2015B050501003]
- Guangdong Provincial Engineering Center For Major Neurological Disease Treatment
- Guangdong Provincial Translational Medicine Innovation Platform for Diagnosis and Treatment of Major Neurological Disease
- Guangdong Provincial Clinical Research Center for Neurological Diseases
Acetylcholine receptor (AChR)-specific CD4+ T cells play a driving role in myasthenia gravis (MG) by regulating the production of autoantibodies. However, the quantitative features of AChR-specific T cells and their clinical significance in MG are unclear. In this study, we adopted standard and cultured enzyme-linked immunosorbent spot (ELISPOT) assays to quantify subpopulations of AChR-specific CD4+ T cells in MG patients, and evaluate their correlation with clinical characteristics. The results showed that Th1- and Th17-AChR-specific CD4+ T cells were detectable by standard and cultured ELISPOT assay respectively, with higher levels observed in MG patients comparing with healthy controls. The number of Th17-AChR-specific CD4+ T cells was positively correlated with anti-AChR antibody titer and quantitative MG score and may have latent capacity to reflect responses to immunosuppressants. These results highlight the differences in quantitative features of AChR-specific CD4+ T cells and imply Th17-AChR-specific CD4+ T cells can serve as a biomarker in MG.
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