期刊
CLINICAL AND EXPERIMENTAL MEDICINE
卷 21, 期 2, 页码 195-204出版社
SPRINGER-VERLAG ITALIA SRL
DOI: 10.1007/s10238-020-00649-w
关键词
Colorectal cancer (CRC); Genomic profile; Immune cells; Immunotherapy
资金
- projects of the Slovak Research and development Agency APVV from the Ministry of Education, Science, Research and Sport of the Slovak republic [APVV-16-0066, VEGA 1/0380/18]
- Biomedical Center Martin - European Union [ITMS 26220220187]
- European Social Fund
Colorectal cancer (CRC) is a leading cancer in both genders, and the TNM staging system is commonly used for tumor classification and prognosis. Recent studies have shown that T-cell infiltration is not uniform and memory T-cells and CD8 cells may play a crucial role in predicting disease-free survival and overall survival in CRC patients. Factors such as immune cell-associated proteins and gene profiles, as well as immunotherapy, are important in determining the outcome of CRC patients.
Colorectal cancer (CRC) is one of the leading cancers in both genders. TNM staging system is still the most commonly used tumor classification and prognostic system. The disadvantage of TNM is that the prognostic information it provides is incomplete, and patients with the same histological tumor stages may differ significantly in the clinical outcome. Therefore, the identification of new prognostic parameters is crucial. The carcinogenic process that gives rise to an individual tumor is unique and tumor microenviroment should be taken into consideration. In CRC, T-cell infiltration is not homogenous, and recent studies are mostly focusing on memory T-cells and CD8 cells in predicting disease-free survival (DFS) and overall survival (OS). It seems that DFS and OS are not only dependent on microsatellite instable or stable status but mostly on the levels of expression of the immune signatures. Also, patients with high infiltration of cytotoxic and memory cells have significantly better outcome. This review consolidates current knowledge and recent research about importance of immune-cell-associated proteins, specific gene profiles of immune cells and immunotherapy in CRC. We also discussed cell-specific signatures in cancer treatment.
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